01). Our data demonstrated that OEA and PSN632408 can stimulate beta-cell replication in vitro and in vivo and improve islet graft function. Targeting GPR119 is a novel therapeutic approach to increase beta-cell mass and to improve islet graft function by stimulating beta-cell replication.”
“The testing of the common mode transfer characteristics of Ethernet transformers with (and

without) inductive chokes is presented. The experimental results are compared selleck with analytical models of common mode transfer functions of Ethernet transformers. The theory and experiment data are found to be in good agreement. (C) 2011 American Institute of Physics. [doi:10.1063/1.3536665]“
“Purpose: To evaluate the feasibility of MR imaging to depict the in vivo recruitment of superparamagnetic iron oxide (SPIO)labeled macrophages and to aid diagnosis of graft rejection in kidney transplantation.

Materials and Methods: This study was approved by the institution’s committee on animal research. Eighteen male Lewis rats received a kidney transplant; 12 had an F344 rat donor and six had a Lewis rat donor. Peritoneal macrophages were harvested from thioglycollate-treated

Lewis rats, cultured, and labeled with SPIO. After resuspension of macrophages in a concentration of 1 x 10(7) cells per milliliter of Hanks balanced salt solution, 5 x 10(6) of SPIO-labeled macrophages was administered through the tail vein 2 or 5 days after transplantation in each group. The transplanted kidneys were imaged on a 4.7-T MR imager 24 hours after 3-MA ic50 macrophage administration. The Wilcoxon signed rank test was performed for evaluating the differences between the relative signal intensity (SI) before and after SPIO-labeled macrophage administration.

Results: A low-SI zone was predominantly noted in the medulla of the transplanted kidneys, and the relative SI decreased significantly from 1.40 to 0.53 (P < .001) in the allogeneic transplants following SPIO-labeled macrophage administration 5 days after the allogeneic transplantation. In the syngeneic group, the lower-SI zone was not noted in the grafts. At histopathologic

examination, the lower-SI zone corresponded to the distribution https://www.selleckchem.com/products/BMS-777607.html of the SPIO-labeled macrophages.

Conclusion: This study demonstrates that the homing of intravenously administered SPIO-labeled macrophages can be monitored in the allograft rejection model on in vivo MR images. (C) RSNA, 2010″
“Toroidal 32- and 64-turn transformers with a unity turn ratio and a silicon dioxide core material were fabricated and tested. The resulting differential mode transfer relation is analyzed with infinite and 100 Omega resistive loads. The best performance is found for a 32-turn transformer with a 100 Omega load, having a relatively flat transfer relation in the frequency range of 10-40 MHz. (C) 2011 American Institute of Physics. [doi:10.1063/1.

In conclusion, non-reentrant DVR SVT is a rare form of tachycardia that should be considered in the differential diagnosis of SVT in children after repair of congenital heart diseases. It is amenable to mapping and RF catheter ablation.”
“Technology of industrial production

of an active pharmaceutical substance (APS) of the recombinant human granulocyte colony-stimulating factor (rhG-CSF) involved the use of a highly productive E. coli strain capable of biosynthesis of rhG-CSF in the form of inclusion bodies (IB). A method of strain cultivation has been described, and methods of HSP targets IB isolation, industrial-scale purification, filgrastim APS production, and quality control

have been developed. Clinical trials of the preparation, HSP990 mw carried out in the leading Russian clinics, were successful. Efficiency and safety of the preparation have been confirmed. A ready pharmaceutical form Neupomax (R) has been produced in Russia since 2008 according to the technology developed.”
“Pectus carinatum is a protrusion deformity of the anterior chest wall that is most likely caused by a disproportionate growth of the costal cartilages compared with the remainder of the thoracic skeleton. A young boy had previously undergone corrective congenital heart operation, after which a prominent sternal protrusion was noted. During the past year, the protrusion had greatly increased in size and had become recurrently infected. Chest X-ray showed that a sternal wire, the ends of which were pointing toward the skin, had straightened. Operative intervention included removal of the offending wire, draining a chronic abscess, and shaving the protruding sternum so that it conformed to the rest of the sternum.”
“Deep

desulfurization of oil and its fractions is currently performed by hydration at high temperature and hydrogen pressure, which makes the process rather expensive. Searches for alternative modes for desulfurization, among which is biodesulfurization, are intensely in progress. In this review, the following subjects are discussed: microorganisms capable of AZ 628 in vitro desulfurizing petroleum products, mechanisms of their activity, achievements in the field of process development, and disadvantages of the method. The existing level of knowledge is insufficient for immediate implementation of an industrial biotechnological process for sulfur elimination from oil and motor fuel and it can only be regarded as a medium-term (10-15 years) prospect.”
“Left-ventricular noncompaction (LVNC) is a rare congenital cardiomyopathy of emerging importance. It is known to occur in association with genetic syndromes. We report here for the first time an infant with LVNC in association with trisomy 21.

We describe a family in whom 5 of 11 children were affected by a unilateral or bilateral congenital aural atresia. Four of these 5 carried a 22q11.2 microduplication and had typical dysmorphic features. Computed tomography with 3-D reconstructions allowed selleck for a detailed examination of the middle ear structures and classification of the atresia type. Audiometry revealed a moderately severe conductive hearing loss in accordance with the clinical and computed tomography findings.

Conclusion: Detailed examination of the ear is warranted in patients with

a 22q11.2 microduplication. When outer ear abnormalities are encountered, an additional workup including audiometry and computed tomography with 3-D reconstructions is required.”
“Bow hunter’s stroke is typically

due to mechanical compression or stretching of the dominant vertebral artery (VA) during contralateral head rotation against the bony elements of the atlas and axis. We report a case of vertebrobasilar insufficiency due to bilateral vertebral artery occlusion at the left C3-4 and the right C1-2 junction on rightward head rotation. A 64-year-old man experienced ischemic symptoms during 90 degrees head rotation to the right with complete resolution of symptoms after returning his head to the neutral position. Dynamic cervical PFTα chemical structure angiography with rightward head rotation showed severe compression VX-680 purchase of the right VA at the transverse foramen of C3-4 and mechanical stenosis of the left VA at the C1-2 level. During head rotation, the flow of the right VA was decreased more than the left side. Cervical 3-D computed tomography (CT) on rightward head rotation demonstrated displacement of the uncovertebral C3-4 joint, with excessive rotation of the C3 vertebral body. Based on these findings, instability at C3-4 was suspected to be the main cause of the vertebrobasilar insufficiency. Anterior discectomy and fusion at the C3/4 level were performed. Postoperatively, the patient experienced complete resolution of symptoms, and dynamic cervical angiography showed disappearance of the

compression of the right VA. To our knowledge, this is the first reported case of bow hunter’s stroke diagnosed by dynamic cerebral angiography and cervical 3-D CT without angiography, and treated by anterior decompression and fusion without decompression of the VA.”
“Chylous fistula is a kind of complication during neck dissection that rarely happens, but might lead to some serious clinical outcome. The standard treatments include local compressive bandaging, negative pressure drainage, ligation of the fistula orifice, alimentary control, and, occasionally, the use of somatostatin. Among them, the simplest is compressive bandaging, but the bandage can easily become loosened and cannot achieve the necessary pressure effect.

The researchers looked at the ability of 29 analytes to discriminate between QFT-positive supernatants

as active TB or LTBI and to differentiate between TB cases and contacts regardless of QFT results. They found that unstimulated levels of EGF (EGF(Nil)) marker showed a sensitivity of 91.3% and a specificity of 79.4% in discriminating between TB patients and contacts regardless of QFT results. The EGF(Ag-Nil) marker showed a sensitivity of 91.2% and a specificity of 82.6%. The sCD40L(Nil) marker showed a sensitivity of 86.9% and a specificity of 79.4%. They found that combinations of analytes are more promising than individual analytes. The top individual analytes were EGF(Nil), EGF(Ag), EGF(Ag-Nil), sCD40L(Nil), and MIP-1 beta(Ag-Nil). It was concluded that multiple biomarkers measured in QFT supernatants show the potential to discriminate accurately GSK923295 research buy between active TB and the absence of active disease. So these researchers propose a two-step test system: 1) IFN-gamma or IP-10 detection to diagnose M. tuberculosis infection, and 2) measurement of the levels of EGF or MIP-1 beta to differentiate positive PFTα Apoptosis inhibitor IFN-gamma or IP-10 results as active TB or LTBI. This approach holds promise and should be pursued for development as a rapid test for active TB.”
“Purpose

Reduced strength and shear stiffness (SS) of lumbar motion segments following laminectomy may lead to instability. The purpose of the present study was to assess a broad range of parameters as potential predictors of shear biomechanical properties of the lumbar spine.

Methods Radiographs and MRI of all lumbar spines were obtained to classify geometry and degeneration of the motion segments. Additionally, dual X-ray absorptiometry (DXA) scans were performed to measure bone mineral content and density (BMC and BMD). Facet sparing lumbar laminectomy was performed either on L2 or L4, in 10 human cadaveric

lumbar spines (mean age 72.1 years, range 53-89 years). Spinal motion segments were dissected (L2-L3 and L4-L5) and tested in shear, under simultaneously loading with 1600 N axial compression. Shear stiffness, shear VDA inhibitor yield force (SYF) and shear force to failure (SFF) were determined and statistical correlations with all parameters were established.

Results Following laminectomy, SS, SYF, and SFF declined (by respectively 24, 41, and 44%). For segments with laminectomy, SS was significantly correlated with intervertebral disc degeneration and facet joint degeneration (Pfirrmann: r = 0.64; Griffith: r = 0.70; Lane: r = 0.73 and Pathria: r = 0.64), SYF was correlated with intervertebral disc geometry (r = 0.66 for length; r = 0.66 for surface and r = 0.68 for volume), BMC (r = 0.65) and frontal area (r = 0.75), and SFF was correlated with disc length (r = 0.73) and BMC (r = 0.81). For untreated segments, SS was significantly correlated with facet joint tropism (r = 0.71), SYF was correlated with pedicle geometry (r = 0.

In vitro angiogenesis assays on

DENV-2 exposed SK Hep1 cells in the matrigel system showed inhibition compared with the controls. Importantly, transfection and transient expression of the DENV-2 envelope glycoprotein (E) in these cells showed drastic alterations in cell shapes and the E protein Selleckchem AC220 could be localized by fluorescence microscopy in terminal knob-like structures. Therefore, SK Hep1, a human hepatic sinusoid-derived endothelial cell line, may constitute a potential model to study DENV-endothelial cell interactions in vitro, especially towards understanding the possible virus-induced changes in hepatic endothelium and its role in disease pathogenesis.”
“Purpose: To evaluate a susceptibility-corrected multiecho magnetic resonance Flavopiridol Cell Cycle inhibitor (MR) relaxometry technique for an accurate and robust determination of Delta R2(star) as a noninvasive surrogate parameter of the perfused tumor blood volume.

Materials and Methods: All experiments were approved by the institutional animal care committee. In a glass tube phantom with different superparamagnetic iron oxide (SPIO) particle concentrations and at tumor mice xenografts with DU-4475, HT-1080, and MDA-MB-435 tumors (n = 15 total, n = 5 per model) with different degrees of neovascularization after injection of different ultrasmall SPIO (USPIO) doses changes of the transverse relaxation rate (Delta R2(star)) were determined by using

a fixed echo time (TE) of 22 msec and a susceptibility-corrected multigradient-echo technique. The mean Delta R2(star) value and the vascular volume fraction (VVF) of each tumor was determined and compared with independent in vivo fluorescent tumor perfusion measurements and histologic analysis helped determine microvessel density (MVD). Statistical differences were tested by using analysis of variance and linear correlations.

Results: For the

phantom study, Delta R2(star) maps calculated with a fixed TE of 22 msec showed a higher standard deviation of the noise index compared with the susceptibility-corrected multiecho technique. For the xenograft model, mean tumor Delta R2(star) values (+/- standard error of the mean) showed signifi cant differences between the various tumors (eg, DU-4475: 12.3 sec(-1) AZD1208 +/- 2.67, HT-1080: 36.47 sec(-1) +/- 5.84, and MDA-MB-435: 64.01 sec(-1) +/- 8.87 at 80 mu mol of iron per kilogram; P< .05). Delta R2(star) values increased dose dependently and in a linear fashion, resulting in reproducibly stable VVF measurements. Fluorescent tumor perfusion measurements and MVD counts corroborated the MR results.

Conclusion: Susceptibility-corrected multiecho MR relaxometry allows a highly accurate and robust determination of Delta R2(star) and VVF with an excellent dynamic range for tumor characterization at clinically relevant doses of USPIO.”
“This paper presents an analytical model for the internal capacitances of short-channel ion-implanted GaAs MESFETs under dark and illuminated conditions.

urealyticum colonization. Users of intrauterine devices had an increased risk of bacterial vaginosis or of contracting U. urealyticum, Mycoplasma hominis and Candida species. Genital complaints were an independent indicator of Candida species, Gram-negative and Gram-positive bacteria, Trichomonas vaginalis and bacterial vaginosis.Chlamydia trachomatis

infections were often asymptomatic. It is concluded that the hormonal milieu and non-physiological factors are major determinants check details of the vaginal flora. If diagnosis of genital infections is based on symptoms alone and not on culture results, it may be erroneous. Sexual abuse should be investigated when a child presents with a sexually transmitted disease.”
“The IPI-145 cost limiting factor

for successful hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GvHD), a post-transplant disorder that results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. Mouse models of GvHD have provided important insights into the pathophysiology of this disease, which have helped to improve the success rate of HSCT in humans. The kinetics with which GvHD develops distinguishes acute from chronic GvHD, and it is clear from studies of mouse models of GvHD (and studies of human HSCT) that the pathophysiology of these two forms is also distinct. Mouse models also further the basic understanding of the immunological responses involved in GvHD pathology, such as antigen recognition and presentation, the involvement of the thymus and immune reconstitution after transplantation. In this Perspective, we provide an overview of

currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical opportunities for the future.”
“Introduction and objectives: To determine whether mortality from acute myocardial infarction has reduced in Spain and the possibly related therapeutic factors.

Methods: Nine thousand, nine hundred and forty-nine patients with ST-segment elevation myocardial Lazertinib supplier infarction admitted to the Coronary Care Unit were identified from PRIAMHO I, II and MASCARA registries performed in 1995, 2000 and 2005, with a 6 month follow-up.

Results: From 1995 to 2005 patients were increasingly more likely to have hypertension, hyperlipidemia and anterior infarction, but age of onset and the proportion of females did not increase. Twenty-eight-day mortality rates were 12.6%, 12.3% and 6% in 1995, 2000 and 2005 respectively, and 15.3%, 14.6% and 9.4% at 6 months (both P-trend <.001). Multivariate analysis was performed and the adjusted odds ratio for 28-day mortality for an infarction occuring in 2005 (compared with 1995) was 0.62 (95% confidence interval: 0.44-0.88) whereas the adjusted hazard ratio for mortality at 6 months was 0.40 (95% confidence interval: 0.24-0.67).

We show that solid-state amorphization can be considered as an extension of a melting transition at low temperature under polymorphic constraints. This theory can also

address endothermic melting as well as exothermic melting at low temperature. We present phase diagrams and the corresponding thermodynamic quantities for a model binary crystalline solution system at and near the transitions. (C) 2011 American Institute of Physics. [doi:10.1063/1.3583671]“
“Purpose To investigate cytokine- and oxidation-related genes for preeclampsia using DNA microarray analysis.

Methods Placentas were collected from 13 normal pregnancies and 13 patients with preeclampsia. Gene expression was studied using DNA microarray. Among significantly expressed genes, we focused on genes associated with cytokines and oxidation, and the results were confirmed using quantitative real time-polymerase chain reaction (QRT-PCR).

Results 415 genes out of NVP-HSP990 30,940 genes

were altered by >= 2-fold in the microarray analysis. 121 up-regulated genes and 294 down-regulated genes were found to be in preeclamptic placenta. Six cytokine-related genes and 5 oxidation-related genes were found from among the 121 up-regulated genes. AG-014699 supplier The cytokine-related genes studied included oncostatin M (OSM), fms-related tyrosine kinase (FLT1) and vascular endothelial growth factor A (VEGFA), and the oxidation-related genes studied included spermine oxidase (SMOX), 1 cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1), acetate dehydrogenase A (LDHA). These Selleck Omipalisib six genes were also significantly higher in placentas from patients with preeclampsia than in those from women with normal pregnancies. The placental tissue of patients with preeclampsia showed significantly higher mRNA expression of these six genes than the normal group, using QRT-PCR.

Conclusion DNA microarray analysis is one of the great methods for simultaneously detecting the functionally associated genes of

preeclampsia. The cytokine-related genes such as OSM, FLT1 and VEGFA, and the oxidation-related genes such as LDHA, CYP26A1 and SMOX might prove to be the starting point in the elucidation of the pathogenesis of preeclampsia.”
“Human immunodeficiency virus-1 (HIV) infection of the central nervous system may cause a neurological syndrome termed HIV-associated neurocognitive disorder (HAND) which includes minor neurocognitive disorders or a more severe form of motor and cognitive impairments. Although treatment with highly active antiretroviral agents decreases the load of HIV in the brain, the prevalence of mild forms of HAND is actually increased due to longer life. Therefore, adjunctive and combined therapies must be developed to prevent and perhaps reverse the neurologic deficits observed in individuals with HAND. Key to developing effective therapies is a better understanding of the molecular and cellular mechanisms by which the virus causes this disorder.

765, 95% CI = 1.307-10.85, p = 0.0095). Modeling interaction between P1371Q and R30Q showed a significant increase in disease association (OR = 2.265, 95% CI = 1.405-3.652, p = 0.0007) incidence for sporadic and familial IBD patients. Further epistatic analysis identified an increased significance in the association of gender with IBD (OR = 4.311, 95% CI = 2.101-8.846, p = 0.0001).

CONCLUSIONS: DLG5 P1371Q was associated PI3K inhibitor with IBD and this association was female-specific. A significant epistatic interaction between P1371Q and R30Q was observed, suggesting that P1371Q is complementary to R30Q, with R30Q exhibiting a dominant

effect in IBD susceptibility.”
“CoPt magnetic nanocrystals have been synthesized in a range of size from 2 to 4 nm using a colloidal chemical synthetic method. As-synthesized nanocrystals exhibit an equiatomic composition and a crystalline phase of type alloy CoPt A1 disordered. The morphology and the magnetic properties were investigated for different crystal size. In order to reach the crystalline transition toward the L1(0) ordered phase, a thermal annealing has been carried

out on CoPt nanocrystals of 4 nm. We showed that the use of HOPG substrate both limits the coalescence effects and promotes the structural ordering. The modification of the crystalline structure selected area electron diffraction (SAED) and the magnetic properties (superconducting quantum interference device) has been studied for different heat-treatment conditions. www.selleckchem.com/products/etomoxir-na-salt.html Ferromagnetic properties at room temperature were achieved for nanocrystals of 16 nm in average size with a coercivity of 4 kOe. (C) 2011 American Institute of Physics. [doi:10.1063/1.3575333]“
“QUESTIONS UNDER STUDY: Prevalence of symptoms, with a focus on fatigue, and changes of symptoms were explored over three months in outpatients with lymphoma, lung, breast or colorectal cancer, receiving chemotherapy in the oncology outpatient clinic of a Swiss tertiary care hospital.

METHODS: Prospective, descriptive design;

symptom prevalence was measured at start of chemotherapy (T1), and one week prior to the third and fourth cycle (T2, T3). Included were patients starting chemotherapy, GSK923295 Cytoskeletal Signaling inhibitor with expected survival of > 3 months, irrespective of stage of disease. The Memorial Symptom Assessment Scale was used to assess 32 symptoms; fatigue was measured with the FACIT-Fatigue Scale (negative scale). Data were analysed using descriptive statistics and random-intercept regression models.

RESULTS: 77 patients participated at T1, 58 and 50 at T2 and T3. Patients experienced on average 9.8, 14.4, and 13.7 symptoms, showing a significant increase over time. Lack of energy and feeling drowsy were most frequent. Symptom scores for lack of energy, changes in skin, pain, and feeling drowsy remained > 2 over time (scale 0-4, higher scores = more symptoms). Fatigue mean scores were 36.3, 30.2, and 31.

Recent findings

Recent studies improve the knowledge in the hemostatic response in cirrhotic patients such as thrombin generation and platelet adhesion due to elevated levels of von AG-881 price Willebrand factor. Restrictive fluid therapy is an important measure to avoid hemodilution and so bleeding. Prophylaxis with antifibrinolytics is being questioned for the risk of thrombosis. Correction of coagulation defects with fresh frozen plasma has not reduced blood loss, and

it has been related to worse outcome. Also, platelets administration has a negative effect in the outcome.

Summary

In order to maintain hemostatic system in compensated cirrhotic patient, every effort we do to improve

it must consider not to imbalance it resulting in thrombi-hemorrhagic events. CA4P Pharmacological measures must be based on their clinical evidence. Identification of high risk bleeding patients would help in developing coagulation guidelines.”
“Purpose To identify potential prognostic factors predicting functional outcome and survival after surgery followed by radiotherapy for metastatic spinal cord compression due to solid tumors.

Methods 531 consecutive patients with metastatic epidural spinal cord compression (MESCC) were treated at our institution. Surgery followed by radiation therapy was performed in 151 patients (30%) with various histological diagnoses. Three different surgical CBL0137 nmr procedures were performed: minimal resection with or without instrumented fixation, curettage, and total tumorectomy. Within 1 month after surgery, RT was performed, delivering a total dose of 30-36 Gy (3 Gy per fraction). Ten potential prognostic factors were investigated for relationship with functional outcome and survival.

Results Clinical remission of pain was obtained in 91% of patients and 94 (62.5%) had recovery of neurological deficit. Recurrence in the same site of treatment occurred in nine (6%) patients. Median survival was 14 months (range 0-52 months); OS at 1, 2, and 3 years was 43.6, 37, and 21.5%, respectively. Survival was significantly

associated with the histology of primary tumor (P < 0.001) and visceral metastases (P < 0.001) in the whole group; for histology, the prognostic factors statistically significant were other bone metastases in breast cancer, control of primary tumor, and the absence of visceral metastases in NSCLC and kind of surgery in the other.

Conclusions The key element for successful treatment of MESCC is multidisciplinary care of the patient, which includes all of those prognostic factors that have been, until now, analyzed and compared. In our set of patients treated for vertebral metastases, PS, time to development of symptoms, and the presence of visceral metastases affected functional outcome and survival.

The dual function of autophagy in tumorigenesis and the implications of autophagy modulation for cancer therapy are also discussed.”
“Aims: The utility of fenestrated-endovascular aneurysm repair (FEVAR) remains uncertain. This study examines the medium term outcomes of patients undergoing FEVAR for asymptomatic juxtarenal abdominal aortic aneurysm (AAA).

Methods: Consecutive patients undergoing elective FEVAR for juxtarenal AAA at a single tertiary centre were studied between October 2005 and March 2010. Patients were followed up for at least six-months within a protocol including clinical examination, laboratory studies,

CT and duplex imaging, and abdominal radiographs. Outcomes were assessed in terms of survival, target vessel patency Z-DEVD-FMK and graft related complications.

Results: Twenty-nine patients were analysed on an intention to treat basis. There were 27 men and two women of median (range) age 74 (54-86) years. Mean (SD) aneurysm diameter was 68 (7) mm. Median (range) ASA score was 3 (2-4). No procedures required conversion to an open procedure, but one procedure was abandoned. Seventy-nine visceral vessels were perfused through a fabric fenestration

or scallop. All vessels remained patent at Emricasan mouse completion angiography. No patients died within 30-days of surgery. During follow up there were four (14%) deaths at a median (range) of 17 (8-21) months after aneurysm repair. None of these deaths https://www.selleckchem.com/products/cbl0137-cbl-0137.html were aneurysm related. Eighteen (62%) patients suffered one or more graft related complications, of whom 11 (38%) required one or more early or late reintervention.

Conclusions: Fenestrated aortic endografts can be utilized safely in the management of juxtarenal AAA in patients at high-risk for open surgery. However, the rate of graft related complication and reintervention is high at medium term follow up. (C) 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“Objective: To evaluate the effect of anti-VEGF (bevacizumab) injection to the

posterior chamber (BIPC) behind the iris combined with seton implantation in treatment of neovascular glaucoma (NVG).

Methods: Twenty-eight eyes with NVG who underwent BIPC, prospectively evaluated. Anterior segment photographs were taken for grading of neovascularization on anterior segment in pretreatment period and at each follow-up. Grading and regression of rubeosis iridis was classified according to Teich and Walsh grading system and glaucoma filtration surgery with drainage device was performed following BIPC.

Results: The mean pre-BIPC IOP was 39.71 +/- 7.09 mmHg, post-BIPC IOP in the 1st, 2nd day, 1st week, 1st, 3rd, 6th month were 19.7 +/- 8.9 mmHg, 13.5 +/- 6.7 mmHg, 9.9 +/- 3.4 mmHg, 13.07 +/- 5.3 mmHg, 16.6 +/- 5.03 mmHg, 18.5 +/- 3.8 mmHg, respectively. Twenty seven eyes underwent seton implantation surgery.