A selection bias may also have affected our results, because the data included in the present study were derived from single-center-based registrations. Nevertheless, our observations suggest that there is a potential relationship between the amount of urinary excreted Klotho and the residual renal function among PD patients, and this relationship will need to be confirmed in further studies including a larger number of PD patients. Moreover, the significant difference in the amount of urinary Klotho between PD patients and normal control subjects demonstrated in the present study led us to propose that there might be a continuum in the relationship between
Akt inhibitor the amount of urinary Klotho and renal function, characterized by the GFR, among subjects with or without chronic kidney disease. On the other hand, the clinical impact of the serum level of Klotho on renal function might need to be evaluated more carefully, because it has been demonstrated that the STAT inhibitor levels of serum Klotho in patients with early stages of chronic kidney disease were observed
to be increased in comparison to those in healthy control subjects . Whether the findings demonstrated in the present study can also be demonstrated in subjects with various stages of chronic kidney disease is currently being investigated by our group. Conflict of interest None declared. References 1. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45–51.PubMedCrossRef 2. Kuro-o M. Klotho. Pflugers Arch. 2010;459:333–43.PubMedCrossRef
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