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“Background Over the past 30 years, the search for bioactive secondary metabolites (natural products) from marine organisms has yielded a wealth of new molecules (estimated at ~17,000) with many fundamentally new chemotypes and extraordinary potential for biomedical research and applications [, and previous references therein]. Marine cyanobacteria continue to be among the most fruitful sources of marine natural products, with nearly 700 compounds described [2, 3].