Third, we did not investigate the molecular mechanism and signal pathways of Hsp90-beta and annexin A1. Hence, RNA interference, gene transfection, and antibody neutralization should be performed to elucidate further the mutual regulation-mechanism regarding lung cancer cell lines. A detailed understanding of the function and significance of Hsp90-beta A-1210477 molecular weight and annexin A1 is advantageous to elucidate further the biological mechanisms of lung cancer and aid in the design of preventive treatment because lung
cancer is a highly malignant tumor in the respiratory system. Our preliminary results need to be confirmed by a prospective study including a large number of subjects as well as by the functional analysis of Hsp90-beta and annexin A1 through in vitro studies in the future because the number of study samples in this study is small. Conclusions We demonstrated that Hsp90-beta and annexin A1 were upregulated in lung cancer, and the upregulation
of these molecules in lung cancer was associated with poor post-surgical survival time and malignant tendency of lung cancer patients. These results indicate that the upregulation of Hsp90-beta and annexin A1 was potentially involved learn more in the progression and prognosis of lung cancer. However, a larger number of lung cancer subjects is required for prospective studies, and further studies are required to investigate the potential mechanism of increased in lung cancer. Acknowledgements This study was supported by grants from the National Natural Scientific Foundation of China (No. 81172234) and the Fundamental Research Funds for the Central Universities of China. We are grateful for the technical advice provided by Dr. Du MG (Chaoying Biotech Company, Xi’an, China) and Li J (The Fourth Military Medical University, Xi’an, China). References 1. Gansler T, Brawley OW: Cancer Statistics, 2010. CA Cancer J Clin 2010,60(5):277–300.CrossRef 2. Lim LHK, Pervaiz S: Annexin 1: the new face of an old molecule. FASEB J 2007,21(4):968–975.PubMedCrossRef 3. Silistino-Souza R, Rodrigues-Lisoni
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