A diagnosis Of Castleman’s disease was rendered, taking into consideration cytologic features tares and cell
block findings. Subsequent histopathology confirmed the diagnosis.
A definitive diagnosis of Castleman’s disease on FNA is possible by a combination of cytologic features and cell block technique with an appropriate use of immunohistochemistry. (Acta Cytol 2009;53:316-318)”
“Background: Ultraviolet radiation is harmful for human skin, and photodamaging pathologies such as actinic erythema, are formerly described as a consequence of UV direct Ruboxistaurin mouse effect on DNA and indirectly by local immune reactions. However, the degree of participation of oxidative stress in actinic erythema and the role of antioxidants in photoprotection are still not fully understood.
Objective: To evaluate the possible palliative role check details of a combination of the antioxidants vitamins C and E in human cutaneous erythema when applied topically before and after UV exposure.
Materials and methods: The study included 20 volunteers of phototypes II, II-III and III with no solar exposure for two months prior to the study. The volunteers were submitted to a phototest consisting on the analysis of the minimal erythemal dose (MED) under different treatments:
1. Untreated irradiated skin; 2. Irradiated skin previously treated with vehicle; 3. Irradiated skin previously treated with a combination of vitamins (2.5% vit E-5% vit C): and 4. Skin treated with the antioxidant combination after irradiation. Cutaneous erythema was evaluated 24 h after exposure and the MED was calculated for each treatment.
Results: The application of vehicle did not significantly affect the MED compared to untreated irradiated skin. Application of the antioxidant combination, prior to irradiation, increased the MED in all phototypes compared with untreated irradiated skin with an average increase of 36.9%. Antioxidants applied after exposure promoted an average increase of
the MED by 19.8%.
Conclusions: Combination of topical antioxidants (vitamins C and E) shows photoprotection activity against erythema, mainly owing to their high absorption properties. Moreover, their antioxidant LY294002 inhibitor activity could be considered as additive, and independent of their optical properties. (C) 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“Background: Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. It has been shown that serum magnesium levels were negatively correlated with HOMA-IR (homeostasis model of insulin resistance) index.
Aim: To investigate the relationship between serum magnesium levels with obesity and insulin resistance in childhood.
Methods : Two hundred and three children and adolescents (117 obese children and 86 controls) were included.