We investigated whether TIRAP gene polymorphisms are associated with the development of tuberculosis in a Chinese population. We investigated all the single-nucleotide polymorphisms check details (SNPs) within the TIRAP exon 5 in a case-control study of 212 patients with tuberculosis and 215 controls in a Chinese population. Genotyping was performed to identify the polymorphisms of TIRAP gene by PCR-DNA sequencing method. Haplotypes for the TIRAP gene variants were constructed using Haploview version 4.2. Six polymorphisms of the SNPs listed in the National Center for Biotechnology Information database were detected in these Chinese tuberculosis patients. It was found that both the frequency of the

286A allele (odds ratio (OR) = 13.37; 95% confidence interval (CI) = 0.75-238.3; P < 0.01) and the frequency of 286AG genotype (OR = 13.57; 95% CI = 0.76-242.5; P < 0.01) were significantly higher in patients than in healthy controls. However, two other AS1842856 SNPs, C539T and C558T, reported to be associated with tuberculosis in other populations, were found not to be associated with tuberculosis in this Chinese population. We conclude that TIRAP G286A (D96N) polymorphism is associated with susceptibility to tuberculosis and may be a new risk factor for the development of tuberculosis in China.”
“The aim of this study

was to evaluate the influence of flaxseed diet supplementation on endothelial function in the mesentenc arterial bed of rats Twenty-four rats were divided into 3 groups Control Group (CG 10% protein 5% fiber 7% lipid) Flaxseed Group (FG supplemented with 25% flaxseed 10% protein 7% fiber 11% lipid) and Modified

CB-839 mw Control Group (MCG 10% protein 7% fiber 11% lipid) The blood was obtained by cardiac puncture (after 180 days) and the serum was separated for lipid profile analyses The vasodilator effect of acetylcholine (1100 pmol) was evaluated in the preconstricted isolated rat vascular bed FG showed a 47% increase in HDL C a 22% reduction in LDL-C a 23% reduction in triacylglycerols and an Increased (p<0 05) vasodilator response to acetylcholine in relation to the CG and CMG groups These results suggest that flaxseed has a cardioprotective effect by improving the blood lipid profile and endothelial function (C) 2010 Elsevier Ltd All rights reserved”
“A new expression system for Lactococcus lactis based on the salt inducible BusA promoter and the BusR repressor gene of L lactis MG1363 was developed. To achieve salt induction, the expression of BusR was modulated by introducing mutations to its promoter sequence An activity of 6 0 mu kat l(-1) of the model enzyme Lactobacillus amylovorus alpha-amylase was achieved in the bioreactor cultivation The major advantage of the current expression system is that no additions of inducing agents are needed into bioreactor cultivations (C) 2009 Elsevier B V.