Serum blood urea nitrogen (BUN) and creatinine, blood pressure, LY2835219 price urinary protein, glomerular morphology and the number of GBM anionic sites were measured in the 2 groups on days 0, 7 and 14.
Results: The losartan group had significantly lower urinary protein on days 7 and 14, and higher BUN on day 14, but there were no significant differences between the losartan and control groups in
serum creatinine or blood pressure. Light microscopy indicated reduced mesangial cell proliferation and expansion of the mesangial area in the losartan group relative to controls. There were more GBM anionic sites in the losartan group on days 7 and 14. In addition, all anionic sites on the surface of foot processes of epithelial cells disappeared in the control group but remained in the losartan group.
Conclusions: A rat model of nephropathy indicates that losartan reduces urinary protein and preserves the number of anionic sites on the GBM, but has no apparent effect on hemodynamics.”
“The magnetic properties and magnetocaloric effect of amorphous alloys Ce2Fe23-xMnxB3 (1 <= x <= 6) were investigated. The magnetic
properties are sensitive to the composition. For samples with x <= 3, the low fraction and isolated Fe-Mn antiferromagnetic (AFM) coupling simply align antiparallel to the majority ferromagnetic (FM) order and reduce the total magnetization but cause no noncollinearity; thus they are BI 2536 typical FM materials with T-C decreasing drastically from 336 to 226 K and the magnetization has a sharp drop around respective T-C without thermal hysteresis suggesting a second order phase transition resulting from their amorphous nature. For x=4 and 5, amorphous alloys Ce2Fe23-xMnxB3 experience two transitions: first a paramagnetic (PM)-FM second transition at 143 and 81 K, respectively, and then a FM-spin glass (SG) transition. A PM-SG transition occurs at the freezing temperature (T-f) PCI-32765 concentration about 28.2 K for x=6. The SG behavior in amorphous alloy Ce2Fe23-xMnxB3 can be attributed
to the disordered structure resulting from their amorphous nature and the competition between the Fe-Fe FM coupling and Fe-Mn AFM negative coupling. The magnetic entropy change for alloys Ce2Fe23-xMnxB3 with x <= 3 is calculated using the Maxwell relation. (c) 2009 American Institute of Physics. [DOI: 10.1063/1.3072031]“
“Background: Total knee arthroplasty carries major risks, including death. Conventional studies have compared the mortality rate following total knee arthroplasty with standardized mortality ratios or age and sex-matched populations. The purpose of the present study was to compare the mortality rate in a population of patients who were managed with total knee arthroplasty with that in patients who were awaiting surgery.