J Clin Oncol 2008, 26:527–534.PubMedCrossRef
3. Bethesda M: SEER Cancer Statistics Review, 1975–2010. National Cancer Institute; buy Ispinesib 2012. Available at [http://seer.cancer.gov/statfacts/html/melan.html] (1 July 2013, date last accessed). 4. Jemal A, Siegel R, Xu J, Ward E: Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277–300.PubMedCrossRef 5. Chao C, Martin RC, Ross MI, Reintgen DS, Edwards MJ, Noyes RD, Hagendoorn LJ, Stromberg AJ, McMasters KM: Correlation between prognostic factors and increasing age in melanoma. Ann Surg Oncol 2004, 11:259–264.PubMedCrossRef 6. Conway WC, Faries MB, Nicholl MB, Terando AM, Glass EC, Sim M, Morton DL: Age-related lymphatic dysfunction in melanoma patients. Ann Surg Oncol 2009, 16:1548–1552.PubMedCentralPubMedCrossRef
7. Macdonald JB, Dueck AC, Gray RJ, Wasif N, Swanson DL, Sekulic A, Pockaj BA: Malignant melanoma in the elderly: different regional disease and poorer prognosis. J Cancer Educ 2011, 2:538–543.CrossRef 8. Hegde UP, Chakraborty N, Kerr P, Grant-Kels JM: Melanoma in the elderly patient: relevance of the aging immune system. Clin Dermatol 2009, 27:537–544.PubMedCrossRef 9. Hegde UP, Grant-Kels JM: Metastatic melanoma in the older patient: special considerations. Clin Dermatol 2013, 31:311–316.PubMedCrossRef 10. Eggermont AMM, Robert C: New drugs in melanoma: It’s a whole new world. Eur J Cancer 2011, 47:2150–2157.PubMedCrossRef Niclosamide 11. Wolchok JD, Hodi FS, Weber JS, Allison JP, Urba WJ, Robert C, O’Day SJ, Hoos A, Humphrey R, Berman DM, Lonberg Torin 1 purchase N, Korman AJ: Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma. Ann N Y Acad Sci 2013, 1291:1–13.PubMedCentralPubMedCrossRef 12. Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Tozasertib Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt
I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010, 363:711–723.PubMedCentralPubMedCrossRef 13. Robert C, Thomas L, Bondarenko I, O’Day S, JW MD, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WH Jr, Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, Chen TT, Humphrey R, Hoos A, Wolchok JD: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011, 364:2517–2526.PubMedCrossRef 14. Lebbé C, Weber JS, Maio M, Neyns B, Harmankaya K, Hamid O, O’Day S, Chin KM, Opatt McDowell D, Cykowski L, McHenry B, Wolchok JD: Long-term survival in patients with metastatic melanoma who received ipilimumab in four phase II trials. J Clin Oncol 2013,31(suppl):abstr 9053. 15.