The spilt oil

killed at least 3600 marine birds and an untold number of marine mammals. The alleged recklessness of the oil exploration, followed by the perceived cover up, was another turning point in Alisertib environmental awareness that led to the Clean Water Act and California’s even more rigorous Porter-Cologne Act. Pesticides labeled as “legacy contaminants” today, were a modern miracle five decades ago. DDT was a pesticide that has saved literally millions of human lives from mosquito transmitted diseases such as malaria. As we now know, the acute toxicity and longevity of DDT that helped its creator win a Noble Prize, was also its greatest flaw. Non-target organisms, such as Brown Pelicans and California Sea Lions, experienced precipitous population declines resulting from bioaccumulation of DDT in these higher order predators. Rachel Carson and STA-9090 concentration her now famous book, Silent Spring, rallied the environmental community. A ban on DDT was implemented shortly after the Clean Water Act was signed into law. Currently, Brown Pelicans and California Sea Lions populations are at their highest level

in 40 years and Brown Pelicans have been removed from the endangered species list. The younger scientists quickly pointed to current day problems to illustrate the deficiency in the Clean Water Act. Recent events in the media, such as the Deepwater Horizon oil spill, the Gulf of Mexico dead zone, or Contaminants of Emerging Concern (CECs), all pose threats to “fishable and swimmable” waters in the United States. How can the Clean Water Act be effective if the Deepwater Horizon spilt 4.9 million barrels, 50 times more oil than Platform A 40 years previous? The Gulf

of Mexico Dead Zone results from large-scale eutrophication. Over 17,500 km2 of hypoxic ocean water was estimated in 2011, an area larger than size of Connecticut. The nutrients that drive this large-scale eutrophication emanate from the United States’ largest watershed, the Mississippi Tacrolimus (FK506) River. The Mississippi River drains roughly 40% of the contiguous United States, including massive agri-business that is thought to comprise at least 70% of the nutrient load from this watershed. Annually, the size of the Dead Zone ebbs and swells in direct relationship to the volume discharged from the great Mississippi River. The lack of nutrient standards and follow-up enforcement is a clear example of the Clean Water Act’s failure as an environmental protection policy. The United States Environmental Protection Agency (EPA), established as part of the Clean Water Act legislation, currently has 126 priority pollutants that it routinely regulates. This list has not materially changed since the 1970s. Yet, there are thousands of industrial, pharmaceutical, personal care products, and current use pesticides that are potentially discharged to the aquatic environment, with hundreds more being developed each year.