Owing to anisotropic diffusion and electrical transport properties, charged lattice defects are preferentially eliminated in the direction parallel to the basal plane of bismuth telluride crystal under electric current stressing. The presented current assisted annealing approach can be an efficient postdeposition treatment that prevents from gross grain growth and evaporation of volatile constituents in Bi-Te based nanocrystalline thin films during

high-temperature annealing process. (C) 2010 American Institute of Physics. [doi:10.1063/1.3477184]“
“Objective. The growth and differentiation properties of human dental pulp cells (HDPC) were investigated on a variety of natural FDA approved Drug Library scaffolds, including 2 types of collagen, gelatin, and chitosan.

Study design. Cell attachment and growth rates of HDPC on collagen (type I and type III), gelatin, and chitosan were observed. Alkaline phosphatase (ALP) activity, mRNA expression of differentiation-related genes, and mineralization of the HDPC on each scaffold were assessed.

Results. Dental pulp cells attached and proliferated rapidly on collagen and gelatin, but chitosan did not properly support cell growth. The cells plated on gelatin exhibited high ALP activity,

but not as high as cells plated on collagen. https://www.selleckchem.com/products/frax597.html The expression peak of osteocalcin (OCN) mRNA from cells grown on collagen was found earlier and followed by dentin sialophosphoprotein (DSPP) and dentin matrix protein 1 (DMP-1) mRNA expression. In cells grown on gelatin, however, OCN mRNA transcripts appeared at a later period of culture with no increase in DSPP or DMP-1 mRNA. Intensely mineralized extracellular

matrix was seen in cells grown on collagen, but gelatin did not allow enough mineralization of cells in differentiation-inducing media.

Conclusion. Collagen supported proliferation and differentiation of HDPC, and the expression of DSPP and DMP-1 mRNA was reduced on gelatin. (Oral Surg Oral Med Oral Pinometostat in vivo Pathol Oral Radiol Endod 2009;108:e94-e100)”
“Background: The anti-CD11a mAb efalizumab has been successfully used in patients with moderate to severe psoriasis. Although peripheral blood leukocytes ubiquitously express LFA-1 (CD11a/CD18), it is assumed that efalizumab exerts its effects primarily on T lymphocytes by blocking migration and by interfering with the immunological synapse.

Objective: To test the latter assumption, we asked whether efalizumab interferes with T cell proliferation induced by qualitatively and quantitatively different stimuli.

Methods: We exposed PBMC isolated either from healthy or psoriatic individuals to titrated doses of plate-bound anti-CD3, PHA or allogeneic PBMC. Furthermore we stimulated normal PMBC (i) in the presence of efalizumab and (ii) after preincubation and removal of efalizumab.