Table 2 The results and correlation of TEG® and ROTEM® parameters
in each study for diagnosis, transfusion guidance and prognosis Diagnosis TEG ® Test Study r /ACT k α A MA CL G Comments TEG® Schreiber (2005) PTT Platelet Johansson (2008b) r, k, α, MA and G improved after Tx packages Plotkin (2008) Platelet Park (2009) NO correlation find more to PT/PTT NO correlation to PT/PTT Watters (2010) MA significantly higher post-splenectomy TEG®-PM Nekludov (2007) Reduced platelet response to AA in bleeders Rapid-TEG® Jeger (2009) Platelet/INR Platelet/INR Platelet/INR Cotton (2011) PT/PTT PT/PTT PT/PTT/platelet PT/PTT/platelet No correlation ROTEM ® Test Study CT CFT
α CA MCF CLI ML EXTEM® Rugeri (2006) PT (CA15) Levrat (2008) ELT (CA10) ELT ELT (CLI60) Davenport (2011a) CT, CA, MCF improves after Tx Davenport (2011b) CA5 diagnosis coagulopathy INTEM® Rugeri (2006) PTT PTT / Platelet (CA15) FIBTEM® Rugeri (2006) Fibrinogen (CA10) Transfusion Guidance TEG ® Test Study r / ACT k α A MA CL G Comments Rapid-TEG® Kashuk (2009) Could reduces FFP Tx ROTEM ® Test Study CT CFT α CA MCF CLI ML EXTEM® Schochl (2011) Fosbretabulin manufacturer ROTEM guided FC/PCC reduces RBC and platelet Tx FIBTEM® Schochl (2011) ROTEM guided FC/PCC reduces RBC and platelet
Tx Prognosis TEG ® Test Study r / ACT k α A MA CL G Comments TEG® Plotkin (2008) Increased Tx Park (2008) Mortality Johansson (2008a) TEG guided Tx reduced mortality Carroll (2009) Mortality Mortality TEG®-PM Carroll (2009) Significantly correlated to Tx Rapid-TEG® this website Kashuk (2010) Mortality Kashuk (2012) Mortality Mortality Pezold (2012) Massive Tx; Mortality ROTEM ® Test Study CT CFT α CA MCF CLI ML EXTEM® Schochl (2009) Mortality Doran (2010) Increased Tx Schochl (2010) ROTEM guided Tx reduces mortality INTEM® Leemann (2010) Increased Tx Abbreviations: r, k, α and MA – TEG® parameters; CT,CFT, α, MCF, CA10, CA15, CL30-CL60 – ROTEM® parameters; ACT – activated clotting time; ELT – euglobulin lysis time; FFP – fresh frozen ABT-263 clinical trial plasma; G – maximal elastic modulus (d/sc); PC – platelet concentrate; PCC – prothrombin complex concentrate; Tx – transfusion Results of 12 studies on the use of TEG® or ROTEM® as diagnostics tools Among the studies on TEG® Schreiber et al reported a correlation between r and PTT, and between MA and platelet count [13].