The genes and their characterised roles are shown in Table 1. Table 1 Genes carried on plasmids involved in S. aureus survival and adaptation Gene Class Gene Accession Number/ Locus Tag Function Antimicrobial resistance, biocide resistance and heavy metal resistance aacA/aphD VRA0030 Gentamicin & Kanamycin Resistance aadD PGO1_p21 Neomycin & Kanamycin Resistance aadE SAP049A_002 Ku 0059436 Aminoglycoside Resistance aphA SAP049A_001 Neomycin & Kanamycin Resistance arsC SAP013A_020 Arsenic Resistance bcrA SAP049A_007 Resistance to Bacitracins blaZ pBORa53p07 Penicillin Resistance ble PGO1_p20 Bleomycin Resistance cadA SATW20_p1220 Cadmium Resistance cadDX pKH18_01 _02 Cadmium Resistance cat pTZ4_p2 Chloramphenicol
Resistance click here cfr EF450709 Chloramphenicol, Lincosamides & Linezolid Resistance dfrA PGO1_p48 Trimethoprim Resistance dfrK FN377602 Trimethoprim Resistance ermB SAP013A_023 MLS Group Resistance ermC pKH19_p2 MLS Group Resistance fosB pTZ2162_25 Fosomycin Resistance fusB pUB101_p23
Fusidic Acid Resistance IP1 pBORa53p09 Immunity Protein IP2 SAP099A_005 Immunity Protein linA pKH21_p2 Linezolid Resistance mco SAP019A_028 Copper Resistance merA SAP026A_033 Mercury Resistance mphBM SAP052A_035 Macrolide Resistance mupA SAP082A_042 Mupirocin Resistance qacA SAP066A_020 Biocide Resistance qacC VRA0026 Biocide Resistance qacJ pNVH01_p2 Biocide Resistance sat SAP049A_002 Streptothricin Resistance str pS194_p1 Streptomycin Resistance tcaA SAP082A_032 Teichoplanin Resistance tetK pKH17_02 Tetracycline Resistance tetL FN377602 Tetracycline Resistance tetM SAPIG0957 Tetracycline & Minocycline Resistance vanB VRA0040 Vancomycin Resistance vatA M36022 Streptogramin Resistance vgaA pVGA_p2 Streptogramin Resistance vgaB U82085 Streptogramin Resistance Transfer traA SAP082A_013 Plasmid MAPK Inhibitor Library screening conjugation traB SAP082A_012 Plasmid conjugation traC C1GALT1 SAP082A_011 Plasmid conjugation
traD SAP082A_010 Plasmid conjugation traE SAP082A_009 Plasmid conjugation traF SAP082A_008 Plasmid conjugation traG SAP082A_007 Plasmid conjugation traH SAP082A_006 Plasmid conjugation traI SAP082A_005 Plasmid conjugation traJ SAP082A_004 Plasmid conjugation traK SAP082A_003 Plasmid conjugation traL SAP082A_002 Plasmid conjugation traM SAP082A_001 Plasmid conjugation type III R-M SAP039A_002 Prevents Survival of Foreign DNA in Host Bacterium mob-I AF447813 Mobilisation L gene cas3 SAP039A_001 Helicase of the CRISPR region abiK SAP058A_004 Prevents Bacteriophage Replication C55 pETB_p42 Lantibiotic System that Kills other Bacteria Toxins ETB pETB_p01 Toxin entA SAP048A_010 Toxin entG SAP048A_007 Toxin entJ SAP048A_008 Toxin entP SAP099A_058 Toxin Adherence sdrE SAP041A_028 Adherence to Host Cells Anti-adhesin SAP057A_026 Prevents Adherence MLS, Macrolide & Streptogramins.