Results: In NAs group the response rate in 3 months was 397%, in

Results: In NAs group the response rate in 3 months was 39.7%, in 3 year was 61.3%, and in 5 year was 49.1%. Nevertheless, in Peg-IFN-NAs sequential group, the response rate in 3 months was 50.0%, in 3 year was 67.5%, and in 5 year was 67.6%. 2-year and 5-year cumulative

survival rates in antiviral therapy group were 97.3%, 73.5%, significantly higher than control group (88.2%, 43.5%), P < 0.01. And 2-year and 5-year cumulative recurrence rates in antiviral therapy group were selleck chemicals 13.3% and 76.5%, which were significantly lower than control group (P < 0.05). Than in NAs group, the 5-year cumulative survival rate in Peg-IFN-NAs sequential group (94.4%) was higher, P < 0.01. and the 2-year

and 5-year cumulative recurrence rates (5.1%, 68.3%) were lower, P < 0.01. However, in both NAs group and Peg-IFN-NAs sequential group, the disease progression rates were no significant difference. Conclusion: Antiviral therapy could effectively improve the prognosis of patients with HCC after liver resection / interventional treatment, and the Peg-IFN- NAs sequential therapy could significantly improve the patient's 5-year survival and 2-year and 5-year cumulative recurrence compared with NAs. Key Word(s): 1. pegylated interferon; 2. nucleoside this website analog; 3. HCC; 4. sequential therapy; Presenting Author: YUNTAO BING Additional Authors: ZHISU LIU, QUANYAN LIU Corresponding Author: QUANYAN LIU Affiliations: Zhongnan hospital Objective: Hepatitis B virus (HBV) infection can cause severe liver diseases, including chronic hepatitis and hepatocellular carcinoma (HCC). Glucocorticoids (Gcs) are commonly used to treat various cancers and immunosuppression, which is based on Glucocorticoid receptor (GR)-mediated mechanisms that trigger cell death. However, HBV patients treated with Gcs lead to severe acute hepatitis. The mechanisms that Gcs play the opposite effect on HBV patients are not fully understood. Methods: We studied MAT1A expression

by real-time quantitative polymerase chain reaction and immunobloting. Key Word(s): 1. click here GR; 2. MAT1A; 3. HBV; 4. HCC; Presenting Author: TANGYIN HUA Corresponding Author: TANGYIN HUA Affiliations: The First Affiliated Hospital of Harbin Medical University Objective: To study the effects of As2O3 on invasion and metastasis of hepatoma tumor model. Methods: Hepatoma cell line (Bel-7402 cells) was established. After treated by different density As2O3. The size and weighty of tumor were observed, inhibition ratio of tumor weight were calculated and AFP was detected. The pathology of tumor tissue and lung were examined. Pulmonary metastasis tubercle were counted. The expression of MIF, IL-8, bFGF and HIF-1α were detected by immunohistochemical. Results: We established a tumor model in nude mice of hepatoma cell line.

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